Gene Therapy of Cancer

2013-08-28
 |  Science
Gene Therapy of Cancer

Author: Edmund C. Lattime

Publisher: Academic Press

ISBN: 9780123946324

Category: Science

Page: 554

View: 961

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Gene therapy as a treatment for cancer is at a critical point in its evolution. Exciting new developments in gene targeting and vector technology, coupled with results from the first generation of preclinical and clinical studies have led to the design and testing of new therapeutic approaches. The Third Edition of Gene Therapy of Cancer provides crucial updates on the basic and applied sciences of gene therapy. It offers a comprehensive assessment of the field including the areas of suicide gene therapy, oncogene and suppressor gene targeting, immunotherapy, drug resistance gene therapy, and the genetic modification of stem cells. Researchers at all levels of development, from basic laboratory investigators to clinical practitioners, will find this book to be instructive. Cancer gene therapy, like cancer therapy in general, is evolving rapidly, testing new concepts, targets and pathways, evoking new technologies, and passing new regulatory hurdles. Its essence, however, has not changed: the hope and challenges of returning altered genes to normal, using targeted gene expression to alter the function of both tumor and microenvironment, and in some cases normal cells, and delivering functionally important genes to specific cell types to increase sensitivity to killing or to protect normal cells from cancer therapies. In some instances, gene therapy for cancer forms a continuum from gene repair through the use of molecularly modified cells; the use of viral and non-viral vector based gene delivery to both tumor and tumor microenvironment; the use of viral and gene based vaccines; and development of new gene-based therapeutics. The unique mechanistically chosen vector platforms are at the heart of this technology because they allow for direct and selective cell death and transient to sustained delivery of vaccine molecules or molecules that affect the microenvironment, vasculature, or the immune response. Explains the underlying cancer biology necessary for understanding proposed therapeutic approaches Presents in-depth description of targeting systems and treatment strategies Covers the breadth of gene therapy approaches including immunotherapeutic, drug resistance,oncolytic viruses, as well as regulatory perspectives from both the NCI and FDA

Cancer Gene Therapy

2007-11-03
 |  Medical
Cancer Gene Therapy

Author: David T. Curiel

Publisher: Springer Science & Business Media

ISBN: 9781592597857

Category: Medical

Page: 490

View: 792

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A complete introduction and guide to the latest developments in cancer gene therapy-from bench to bedside. The authors comprehensively review the anticancer genes and gene delivery methods currently available for cancer gene therapy, including the transfer of genetic material into the cancer cells, stimulation of the immune system to recognize and eliminate cancer cells, and the targeting of the nonmalignant stromal cells that support their growth. They also thoroughly examine the advantages and limitations of the different therapies and detail strategies to overcome obstacles to their clinical implementation. Topics of special interest include vector-targeting techniques, the lessons learned to date from clinical trials of cancer gene therapy, and the regulatory guidelines for future trials. Noninvasive techniques to monitor the extent of gene transfer and disease regression during the course of treatment are also discussed.

Current Strategies in Cancer Gene Therapy

2017-01-17
 |  Medical
Current Strategies in Cancer Gene Therapy

Author: Wolfgang Walther

Publisher: Springer

ISBN: 9783319429342

Category: Medical

Page: 121

View: 574

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This book describes important developments and emerging trends in experimental and clinical cancer gene therapy. It reflects the tremendous advances made over recent years with respect to immunogenes, suicide genes and gene correction therapies, as well as in gene suppression and miRNA therapies. Many of the described strategies focus on the generation of more efficient and specific means of attack at known and novel cellular targets associated with tumor development and progression. The book also details parallel improvements in vector design, vector delivery, and therapeutic efficacy. It offers readers a stimulating, broad overview of advances in the field, linking experimental strategies to their clinical applications.

Gene Therapy and Cancer Research Focus

2008
 |  Cancer
Gene Therapy and Cancer Research Focus

Author: Rebecca N. Campbell

Publisher: Nova Publishers

ISBN: 1600219705

Category: Cancer

Page: 354

View: 836

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Genes, which are carried on chromosomes, are the basic physical and functional units of heredity. Genes are specific sequences of bases that encode instructions on how to make proteins. Although genes get a lot of attention, it's the proteins that perform most life functions and even make up the majority of cellular structures. When genes are altered so that the encoded proteins are unable to carry out their normal functions, genetic disorders can result. Gene therapy is an experimental treatment that involves introducing genetic material into a person's cells to fight disease. Gene therapy is being studied in clinical trials for many different types of cancer and for numerous other diseases. The volume presents significant new research results in this promising field.

Gene Therapy for Cancer

2007-10-26
 |  Medical
Gene Therapy for Cancer

Author: Kelly K. Hunt

Publisher: Springer Science & Business Media

ISBN: 9781597452229

Category: Medical

Page: 469

View: 651

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The three sections of this volume present currently available cancer gene therapy techniques. Part I describes the various aspects of gene delivery. In Part II, the contributors discuss strategies and targets for the treatment of cancer. Finally, in Part III, experts discuss the difficulties inherent in bringing gene therapy treatment for cancer to the clinic. This book will prove valuable as the volume of preclinical and clinical data continues to increase.

Gene Therapy and Cancer Research Progress

2008
 |  Cancer
Gene Therapy and Cancer Research Progress

Author: Jessica L. Lewis

Publisher: Nova Publishers

ISBN: 1600218113

Category: Cancer

Page: 240

View: 175

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Genes, which are carried on chromosomes, are the basic physical and functional units of heredity. Genes are specific sequences of bases that encode instructions on how to make proteins. Although genes get a lot of attention, it's the proteins that perform most life functions and even make up the majority of cellular structures. When genes are altered so that the encoded proteins are unable to carry out their normal functions, genetic disorders can result. Gene therapy is an experimental treatment that involves introducing genetic material into a person's cells to fight disease. Gene therapy is being studied in clinical trials for many different types of cancer and for numerous other diseases. This new book presents the latest research in the field from around the world.

Gene Therapy of Cancer

2000
 |  Medical
Gene Therapy of Cancer

Author: Wolfgang Walther

Publisher: Springer Science & Business Media

ISBN: UOM:39015050108920

Category: Medical

Page: 672

View: 469

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Since the discovery of the molecular structure of genes and the unveiling of the molecular basis of numerous human diseases, scientists have been fas- nated with the possibility of treating certain diseases by transducing foreign DNA into the affected cells. Initially, it was proposed that the foreign DNA could either replace defective nonfunctional genes, or code for therapeutic proteins. This concept has evolved into the rapidly growing field of gene therapy. Even though surgery, radiotherapy, and chemotherapy are widely ava- able and routinely used for cancer treatment, these therapies fail to cure approximately 50 percent of cancer patients. Therefore, since it is a disease characterized by aberrant gene expression, cancer has been a target of gene therapy research since the inception of this treatment modality. Numerous cancer gene therapy strategies are currently being investigated, including gene replacement therapy, the regulation of gene expression to modulate immu- logical responses to tumors, the direct killing of tumor cells, and direct int- ference with tumor growth. In this context, gene transfer systems, tumor-specific expression vectors, and novel therapeutic genes have been extensively st- ied. All these strategies aim for the selective destruction of human malignant disease while circumventing the destruction of nonmalignant cells and tissues thereby minimizing toxicity to the patient.

Viral Therapy of Cancer

2008-05-23
 |  Science
Viral Therapy of Cancer

Author: Kevin J. Harrington

Publisher: Wiley

ISBN: 9780470985786

Category: Science

Page: 432

View: 990

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In the last decade there has been an explosion of interest in viral therapies for cancer. Viral agents have been developed that are harmless to normal tissues but selectively able to kill cancer cells. These agents have been endowed with additional selectivity and potency through genetic manipulation. Increasingly these viruses are undergoing evaluation in clinical trials, both as single agents and in combination with standard chemotherapy and radiotherapy. This book provides a comprehensive yet succinct overview of the current status of viral therapy of cancer. Chapters coherently present the advances made with individual agents and review the biological and clinical background to a range of viral therapies: structured to proceed from basic science at the bench to the patient’s bedside, they give an up-to-date and realistic evaluation of a therapy’s potential utility for the cancer patient. Presents state of the art knowledge on how viruses can be, and have been, used in novel therapeutic approaches for the treatment of cancer Describes the use of viruses as oncolytic agents, killing cells directly Editors are experts in the field, with experience of both laboratory and clinical research Viral Therapy of Cancer is essential reading for both basic scientists and clinicians with an interest in viral therapy and gene therapy.

Gene Therapy — From Laboratory to the Clinic

1994-11-29
 |  Science
Gene Therapy — From Laboratory to the Clinic

Author: Kam M Hui

Publisher: World Scientific

ISBN: 9789814502382

Category: Science

Page: 288

View: 752

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With advances in our understanding of the molecular biology of human diseases and the development of efficient gene transfer techniques, the treatment of such diseases as cancer and infectious disease using gene therapy has progressed from a distant prospect to a distinct possibility in a very short time. The development of gene transfer methods which are suitable for different forms of therapy has been a major topic of research over the past several years. A common goal of this research has been to achieve the efficient delivery of genes into cells. The successful implementation of gene transfer as a cure for diseases, however, will continue to require the translation of preclinical studies in gene therapy into effective clinical protocols. This volume outlines the latest developments in cancer treatment using various gene delivery systems, which include cytokine gene transfer, the delivery of anti-ras DNA by retroviral vector and the injection of allogeneic HLA DNA via liposomes. Several of these molecular approaches have recently been approved by the US FDA as human clinical trial protocols in order to assess their therapeutic efficiency and safety for cancer treatment. Further developments in recombinant DNA technology within this field should ultimately lead to dramatic improvements in the practice of medicine. Contents:Foreword (R A Weiss)An Introduction to Gene Therapy and Cancer (Y H Tan)Clinical Strategies and Expectations for the Molecular Biotherapy of Cancer (H K B Silver & R J Klasa)Tumor-Directed Cytokine Gene Therapy (C S Chiang et al.)Therapeutic Applications of Antisense Nuclei Acids (T M C Tan et al.)Molecular Targeting of Cancer: Retroviral Vector-Mediated Antisense Nuclei Acid Therapy (Y Zhang et al.)DC-Chol Liposomes as DNA Carriers for Gene Therapy (A Singhal & L Huang)Accell Particle Bombardment for Gene Transfer as a Useful Gene Therapy Technique (N-S Yang et al.)DNA-Coated Microprojectiles for Gene Delivery into Live Animals (D-C Tang & S A Johnston)Expression of “Foreign” Class I Major Histocompatibility Complex (MHC) Molecules on Experimental Tumors and the Induction of Active Specific Cancer Immunotherapy (K M Hui)Gene Transfer to the Central Nervous System Mediated by Herpes Simplex Virus Vectors (J C Glorioso et al.)Adeno-Associated Virus-Based Vectors for Human Gene Therapy (R J Samulski)Index Readership: Scientists, clinical investigators, physicians and graduate students in medical/ biological sciences. keywords:Human Gene Therapy;Cancer Gene Therapy;DNA Vaccines;Gene Transfer;Viral Vector;Adenovirus;Retrovirus;Non-Viral Vector;Liposomes;Gene Gun “… the format and length of this text makes it an easy to read introduction to the area of gene therapy. It would be ideally suited to the reader with a working knowledge of one particular area of gene therapy who wished to gain a broader perspective of the field. Medical scientists in particular would find this a useful adjunct to their current textbooks.” Cancer Forum

Gene Therapy of Cancer

2002-04-04
 |  Science
Gene Therapy of Cancer

Author: Stanton L. Gerson

Publisher: Elsevier

ISBN: 0080491367

Category: Science

Page: 534

View: 450

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The Second Edition of Gene Therapy of Cancer provides crucial updates on the basic science and ongoing research in this field, examining the state of the art technology in gene therapy and its therapeutic applications to the treatment of cancer. The clinical chapters are improved to include new areas of research and more successful trials. Chapters emphasize the scientific basis of gene therapy using immune, oncogene, antisense, pro-drug activating, and drug resistance gene targets, while other chapters discuss therapeutic approaches and clinical applications. This book is a valuable reference for anyone needing to stay abreast of the latest advances in gene therapy treatment for cancer. Key Features * Provides in-depth description of targeted systems and treatment strategies * Explains the underlying cancer biology necessary for understanding a given therapeutic approach * Extensively covers immune therapeutics of vaccines, cytokines, and peptide-induced responses * Presents translational focus with emphasis on requirements for clinical implementation * Incorporates detailed illustrations of vectors and therapeutic approaches ideal for classroom presentations and general reference