Clinical Trials in Oncology, Third Edition

Clinical Trials in Oncology, Third Edition

Author: Stephanie Green

Publisher: CRC Press

ISBN: 9781439814482

Category: Mathematics

Page: 266

View: 284

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The third edition of the bestselling Clinical Trials in Oncology provides a concise, nontechnical, and thoroughly up-to-date review of methods and issues related to cancer clinical trials. The authors emphasize the importance of proper study design, analysis, and data management and identify the pitfalls inherent in these processes. In addition, the book has been restructured to have separate chapters and expanded discussions on general clinical trials issues, and issues specific to Phases I, II, and III. New sections cover innovations in Phase I designs, randomized Phase II designs, and overcoming the challenges of array data. Although this book focuses on cancer trials, the same issues and concepts are important in any clinical setting. As always, the authors use clear, lucid prose and a multitude of real-world examples to convey the principles of successful trials without the need for a strong statistics or mathematics background. Armed with Clinical Trials in Oncology, Third Edition, clinicians and statisticians can avoid the many hazards that can jeopardize the success of a trial.

Handbook of Statistics in Clinical Oncology, Third Edition

Handbook of Statistics in Clinical Oncology, Third Edition

Author: John Crowley

Publisher: CRC Press

ISBN: 9781439862001

Category: Mathematics

Page: 661

View: 458

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Many new challenges have arisen in the area of oncology clinical trials. New cancer therapies are often based on cytostatic or targeted agents, which pose new challenges in the design and analysis of all phases of trials. The literature on adaptive trial designs and early stopping has been exploding. Inclusion of high-dimensional data and imaging techniques have become common practice, and statistical methods on how to analyse such data have been refined in this area. A compilation of statistical topics relevant to these new advances in cancer research, this third edition of Handbook of Statistics in Clinical Oncology focuses on the design and analysis of oncology clinical trials and translational research. Addressing the many challenges that have arisen since the publication of its predecessor, this third edition covers the newest developments involved in the design and analysis of cancer clinical trials, incorporating updates to all four parts: Phase I trials: Updated recommendations regarding the standard 3 + 3 and continual reassessment approaches, along with new chapters on phase 0 trials and phase I trial design for targeted agents. Phase II trials: Updates to current experience in single-arm and randomized phase II trial designs. New chapters include phase II designs with multiple strata and phase II/III designs. Phase III trials: Many new chapters include interim analyses and early stopping considerations, phase III trial designs for targeted agents and for testing the ability of markers, adaptive trial designs, cure rate survival models, statistical methods of imaging, as well as a thorough review of software for the design and analysis of clinical trials. Exploratory and high-dimensional data analyses: All chapters in this part have been thoroughly updated since the last edition. New chapters address methods for analyzing SNP data and for developing a score based on gene expression data. In addition, chapters on risk calculators and forensic bioinformatics have been added. Accessible to statisticians and oncologists interested in clinical trial methodology, the book is a single-source collection of up-to-date statistical approaches to research in clinical oncology.

Textbook of Clinical Trials in Oncology

Textbook of Clinical Trials in Oncology

Author: Susan Halabi

Publisher: CRC Press

ISBN: 9781351620970

Category: Medical

Page: 626

View: 734

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There is an increasing need for educational resources for statisticians and investigators. Reflecting this, the goal of this book is to provide readers with a sound foundation in the statistical design, conduct, and analysis of clinical trials. Furthermore, it is intended as a guide for statisticians and investigators with minimal clinical trial experience who are interested in pursuing a career in this area. The advancement in genetic and molecular technologies have revolutionized drug development. In recent years, clinical trials have become increasingly sophisticated as they incorporate genomic studies, and efficient designs (such as basket and umbrella trials) have permeated the field. This book offers the requisite background and expert guidance for the innovative statistical design and analysis of clinical trials in oncology. Key Features: Cutting-edge topics with appropriate technical background Built around case studies which give the work a "hands-on" approach Real examples of flaws in previously reported clinical trials and how to avoid them Access to statistical code on the book’s website Chapters written by internationally recognized statisticians from academia and pharmaceutical companies Carefully edited to ensure consistency in style, level, and approach Topics covered include innovating phase I and II designs, trials in immune-oncology and rare diseases, among many others

Fundamentals of Clinical Trials

Fundamentals of Clinical Trials

Author: Lawrence M. Friedman

Publisher: Springer

ISBN: 1441915850

Category: Medical

Page: 445

View: 224

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The clinical trial is “the most definitive tool for evaluation of the applicability of clinical research.” It represents “a key research activity with the potential to improve the quality of health care and control costs through careful comparison of alternative treatments” [1]. It has been called on many occasions, “the gold st- dard” against which all other clinical research is measured. Although many clinical trials are of high quality, a careful reader of the medical literature will notice that a large number have deficiencies in design, conduct, analysis, presentation, and/or interpretation of results. Improvements have occurred over the past few decades, but too many trials are still conducted without adequate attention to its fundamental principles. Certainly, numerous studies could have been upgraded if the authors had had a better understanding of the fundamentals. Since the publication of the first edition of this book, a large number of other texts on clinical trials have appeared, most of which are indicated here [2–21]. Several of them, however, discuss only specific issues involved in clinical trials. Additionally, many are no longer current. The purpose of this fourth edition is to update areas in which major progress has been made since the publication of the third edition. We have revised most chapters considerably and added one on ethical issues.

Instruments for Clinical Health-care Research

Instruments for Clinical Health-care Research

Author: Sharon Olsen

Publisher: Jones & Bartlett Learning

ISBN: 0763722529

Category: Medical

Page: 740

View: 862

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2004 AJN BOOK OF THE YEAR AWARD WINNER! This Text Facilitates Researching Clinical Concepts And Will Enhance The Focus On Linking Clinical Variable Assessments With Routine Measurement Of Everyday Clinical Interventions. With This Book, Students Will Be Able To: Review Available Instruments That Measure Select Clinical Phenomena; Review Selected Studies Employing Each Tool; Identify An Instrument’S Strengths And Weaknesses; And Develop Instruments For Cross-Cultural Research.

Contemporary Issues in Breast Cancer

Contemporary Issues in Breast Cancer

Author: Karen Hassey Dow

Publisher: Jones & Bartlett Learning

ISBN: 0763714828

Category: Medical

Page: 378

View: 906

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This unique book addresses breast cancer in the broad context of the individual, the larger family, and community experiences. Comprehensive chapters on prevention, screening, and treatments cover current research from a nursing perspective. Survivorship, choice and emotional resolution are explored and 'Story as a Way of Knowing' offers insight into the experiences of long-term survivors. Each chapter is comprehensive in its scope of history and current issues and suggests areas of future research.

Quality of Life

Quality of Life

Author: Pamela S. Hinds

Publisher: Jones & Bartlett Learning

ISBN: 0763722359

Category: Medical

Page: 576

View: 196

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This Comprehensive Reference Provides A Unique Perspective On Quality Of Life Issues For Oncology Nurses In Education, Research, And Clinical Practice, And Presents Quality Of Life Issues Related To Specific Diseases, Treatments, And Populations.

Drug Discovery and Development, Third Edition

Drug Discovery and Development, Third Edition

Author: James J. O'Donnell

Publisher: CRC Press

ISBN: 9781351625135

Category: Medical

Page: 860

View: 198

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Drug Discovery and Development, Third Edition presents up-to-date scientific information for maximizing the ability of a multidisciplinary research team to discover and bring new drugs to the marketplace. It explores many scientific advances in new drug discovery and development for areas such as screening technologies, biotechnology approaches, and evaluation of efficacy and safety of drug candidates through preclinical testing. This book also greatly expands the focus on the clinical pharmacology, regulatory, and business aspects of bringing new drugs to the market and offers coverage of essential topics for companies involved in drug development. Historical perspectives and predicted trends are also provided. Features: Highlights emerging scientific fields relevant to drug discovery such as the microbiome, nanotechnology, and cancer immunotherapy; and novel research tools such as CRISPR and DNA-encoded libraries Case study detailing the discovery of the anti-cancer drug, lorlatinib Venture capitalist commentary on trends and best practices in drug discovery and development Comprehensive review of regulations and their impact on drug development, highlighting special populations, orphan drugs, and pharmaceutical compounding Multidiscipline functioning of an Academic Research Enterprise, plus a chapter on Ethical Concerns in Research Contributions by 70+ experts from industry and academia specialists who developed and are practitioners of the science and business

Oncology Nursing Drug Handbook

Oncology Nursing Drug Handbook

Author: Gail M. Wilkes

Publisher: Jones & Bartlett Learning

ISBN: 0763743062

Category: Medical

Page: 1256

View: 776

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2007 Oncology Nursing Drug Handbook is a comprehensive nursing resource for assessment, intervention, and patient education in the administration of oncology drugs. This text reviews drug information from the nurse's point of view, and helps the nurse focus on minimizing toxicity. This essential reference provides valuable information on effective symptom management and chemotherapy administration for the oncology nurse. Revised annually with new drugs, the book also includes updated indications and additional toxicology data for individual drugs.

2006 Oncology Nursing Drug Handbook

2006 Oncology Nursing Drug Handbook

Author: Gail M. Wilkes

Publisher: Jones & Bartlett Learning

ISBN: 0763739235

Category: Medical

Page: 1244

View: 585

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2006 Oncology Nursing Drug Handbook is a comprehensive nursing resource for assessment, intervention, and patient education in the administration of oncology drugs. This text reviews drug information from the nurse's point of view, and helps the nurse focus on minimizing toxicity. This essential reference provides valuable information on effective symptom management and chemotherapy administration for the oncology nurse. Updated annually, the 2006 edition includes the following new drugs: four antineoplastic agents (clofarabine, histrelin implant, paclitaxel protein bound particles for injection, TLK 286), four antimicrobial agents (micafungin, rifaximin, gemifloxacin, tigecycline), two immunotherapy/biotherapy symptom management agents (Imiquimod 5% cream., palifermin), and eight molecularly targeted drugs (lapatanib, panitumumab, pertuzumab, sorafeni (BAY 43-9006), sunitinib malate (sutent, SU11246), temsirolimus, tipifarnib, vatalanib), and one symptom management drug (ziconotide intrathecal infusion). In addition, indications and additional toxicity data have been updated for individual drugs, such as bevacizumab, cetuximab, and gefitinib.

Cancer Symptom Management

Cancer Symptom Management

Author: Connie Henke Yarbro

Publisher: Jones & Bartlett Learning

ISBN: 0763721425

Category: Medical

Page: 784

View: 110

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Accompanying CD-ROM contains customizable patient self-care guides.

Patient Education Guide to Oncology Drugs

Patient Education Guide to Oncology Drugs

Author: Gail M. Wilkes

Publisher: Jones & Bartlett Learning

ISBN: 0763722537

Category: Medical

Page: 580

View: 665

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"The companion CD-ROM is designed to allow health care professionals to customize the instruction sheets for specific situations. These customized sheets can easily be printed out for individual patient use."--Page 4 of cover.